Multiple Myeloma and Protein Electrophoresis
Multiple Myeloma; is a multifocal plasma cell neoplasm that affects the bone marrow and is associated with the production of a serum and urinary monoclonal protein. The cause is a progressive unregulated proliferation of plasma cells that accumulate in the bone marrow. These cells secrete excess immunoglobulin (Ig), usually: IgG 57%; IgA 21%, IgD 1%, IgM, IgE, only rarely in 18% of cases of light chains alone. The proliferation of multiple myeloma interferes with normal cell production in the bone marrow and usually results in anemia.